杜亚楠
电子邮件：duyanan@TSINGHUA.EDU.CN
电话：＋86-10-62781691（实验室）
实验室网站： http://dulab.med.tsinghua.edu.cn/
研究方向：
通过高度交叉和创新形成了微组织工程这一独具特色的研究方向。研究内容为应用微纳加工技术、生物材料和生物力学等手段构建精确可控、具有仿生结构和功能的“定制化”生理和病理3D微尺度组织，为再生医学以及药物筛选和病理研究提供新型平台技术、理论模型和解决方案。
代表性科研论文：
1. Liu L, You Z, Yu H, Zhou L, Zhao H, Yan X, Li D, Wang B, Zhu L, Xu Y, Xia T, Shi Y, Huang C, Hou W, Du, Y*, ‘Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis’ Nature Materials 16(12):1252-1261(2017)
2. Yan X, Zhou L, Wu Z, Wang X, Chen X, Yang F, Guo Y, Wu M, Chen Y, Li W, Wang J*, Du Y*. ‘High throughput scaffold-based 3D micro-tumor array for efficient drug screening and chemosensitivity testing’. Biomaterials. 2018 May doi: 10.1016/j.biomaterials.2018.05.020
3. Fan X, Zhu L, Wang K, Wang B, Wu Y, Xie W, Huang C, Chan BP, Du Y* ‘Stiffness-Controlled Thermoresponsive Hydrogels for Cell Harvesting with Sustained Mechanical Memory’ Adv Healthc Mater. Mar;6(5) doi:10.1002/adhm.201601152. (2017)
4. Qi C, Li Y, Badger P, Yu H, You Z, Yan X, Liu W, Shi Y, Xia T, Dong J, Huang C, Du Y*, ‘Pathology-targeted cell delivery via injectable micro-scaffold capsule mediated by endogenous TGase’ Biomaterials 126:1-9 (2017)
5. Zhu L, Fan X, Wang B, Liu L, Yan X, Zhou L, Zeng Y, Poznansky MC, Wang L, Chen H, Du Y* ‘Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapy’ Biomaterials 124:12-24 (2017)
6. Wang J, Chen F, Liu L, Qi C, Wang B, Yan X, Huang C, Hou W, Zhang M, Chen Y*, Du Y* Engineering EMT using 3D Micro-scaffold to Promote Hepatic Functions for Drug Hepatotoxicity Evaluation’ Biomaterials 91:11-22 (2016)
7. Zeng Y, Chen C, Liu W, Fu Q, Han Z, Li Y, Feng S, Li X, Qi C, Wu J, Wang D, Corbett C, Chan BP, Ruan D*, Du Y*. Injectable Microcryogels Reinforced Alginate Encapsulation of Mesenchymal Stromal Cells for Leak-proof Delivery and Alleviation of Canine Disc Degeneration’ Biomaterials 59:53-65 (2015)
8. Zhao H, Zhou L, Zhang Q, Zhou X, Zhang Y, Chen H, Du Y* ‘Bi-content micro-collagen chip provides contractility-based biomechanical readout for phenotypic drug screening with expanded and profiled targets’ Lab Chip, 15(17):3481-94 (2015)
9. Li Y, Liu W, Liu F, Zeng Y, Zuo S, Feng S, Qi C, Wang B, Khademhosseini A, Bai J, Du Y* ‘Primed 3D Injectable Micro-Niches Enabling Low-dosage Cell Therapy for Critical Limb Ischemia’ PNAS 111(37):13511-6 (2014)
10. Liu W, Li Y, Feng S, Ning J, Chen H, Feng X, Du Y* ‘Magnetically Controllable 3D Microtissues based on Magnetic microcryogels’ Lab on Chip (cover) 4(15):2614-25 (2014)
11. Zhao S, Zhao H, Zhang X, Li Y, Du Y* ‘Off-the-shelf Microsponge Arrays for Facile and Efficient Construction of 3D Cellular Microenvironment for Versatile cell-based assays’ Lab on Chip 13(12):2350-8 (2013)